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A few years ago a study was done of the brain tissue of smokers and non-smokers after theyd died, and scientists found that nicotine caused long-term chemical changes in the brain similar to those caused by heroin, cocaine and other hard drugs
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They detach from the basement membrane, leading to increased vessel permeability, and undergo transdifferentiation into myofibroblasts, resulting in the deposition of collagenous extracellular matrix 25
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