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Genetic testing of affected patients disclosed two patients (2/30, 6.7%) with optic neuropathy associated with pathogenic variants affecting the SPG7 gene and five patients (5/30, 16.7%) who harbored variants of uncertain significance close to probable pathogenicity in the genes WFS1 , LOXL1 , MMP19 , NR2F1 and PMPCA

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In warm and moist areas of the body, such as the anus and labia, large white or grey raised lesions develop as a result of the spread of the treponemes from the primary lesion

When inhaling, instantly you get that tongue-tingling sensation that makes you feel exhilarated