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This difference is why questions continue to surface about how the puffs of a 5% vape compared to the familiar experience of enjoying a cigarette, and whether vaping truly replaces smoking on a puff for puff basis

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A 2018 study funded by the FDA found that lowering nicotine levels in cigarettes could decrease the chances that future generations become addicted to cigarettes, and could make it easier for more currently addicted smokers to quit. The FDA has been mulling over a decision to reduce the levels of nicotine in cigarettes for several years as part of its regulation efforts for tobacco

Weiss et al., 1999

This can lead to various respiratory diseases that have chest pain as a symptom