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An important caveat of this analysis is that we are matching to smoking status as recorded in the medical record

Besides the anti-inflammatory effect prior to cancer, cannabinoids also decrease cancer-induced inflammation (Lyons 2023)

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Withdrawal is characterized by negative affective states (irritability, anxiety, depression, anhedonia) and craving, partly mediated by dopamine deficits and activation of stress pathways involving corticotropin releasing factor