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This is a classic Marlboro Cigarettes print advertisement from the 1990s, specifically from 1999. The ad features a close-up of a cowboy with a rugged and contemplative expression, embodying the iconic Marlboro Man imagery that was prevalent during this era

He was the spark plug, the man with the plan

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Hypoxia, in turn, leads to the HIF-1-dependent upregulation of methionine adenosyltransferase 2A, which is an enzyme that synthesizes S -adenosylmethionine, a major biological methyl donor critical for DNA methylation processes (Liu et al., 2011)

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