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One 2016 study found that vaping using liquids with higher concentrations of flavoring compounds can form more toxic organic compounds called aldehydes, sometimes at levels that exceed federal standards for workplace safety

It is essential to exercise careful supervision over their use due to the considerable potential for misuse

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Firstly, while results from the multivariable MR analysis conceptually help obtain a marginal estimate of the effect size between an exposure of interest and the outcome by conditioning competing risk factors, the model can potentially over-correct true associations as the underlying model does not distinguish between horizontal (independent of causality) and vertical (in line with causality) pleiotropy

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