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MedGenMed 9 , 32 (2007)

Many hobbyists purchase whole leaf tobacco thats already been cured and fermented, then create custom blends

Journal of the National Cancer Institute, 102(20):1584-1598

For female partners exposed to secondhand smoke, there is evidence of: Reduced ovarian reserve Poorer response to ovarian stimulation during IVF Lower embryo implantation rates Higher risk of miscarriage Couples where both partners are exposed to tobacco even passively may therefore have compounded fertility disadvantages that are entirely addressable through cessation

Reformulations force batches to change as do raw material sourcing depending on the season which creates fluctuations while minor, some may get more licorice and find the tobacco hard to pick up