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Chronic use leads to neuroplastic changes, including upregulation of nicotinic receptors, and regular use results in increased tolerance and dependence

4.2 Impact of tobacco smoke exposure and mercury on gut microbiota composition The gut microbiota in healthy children of 7 years old showed a predominance of Bacteroides , Akkermansia , Alistipes , and Faecalibacterium , as described previously (Xiong et al., 2022)

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