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Alzheimers disease and Parkinsons disease are the two most common neurodegenerative diseases, which increases steadily with age and affect tens of millions of people worldwide ( At the cellular level, nicotine activates the 7-nAChR/Elk signaling pathway to reduce the oxidative damage caused by hydrogen peroxide, improve damaged mitochondrial membrane potential, and inhibit the damage to hippocampal neurons induced by excessive accumulation of reactive oxygen species (ROS) ( 25-35 , A 1-40 or A 40-1 in Sprague-Dawley rats and reduces neurotoxicity by decreasing caspase-3 activity, clearing ROS and maintaining Ca 2+ homeostasis (Liu and Zhao, 2004)

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