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Other elements in the TPD also treat these products differently, such as the use of additives and ingredients necessary to produce products that operate differently from combustible cigarettes

It can lead to reduction in oxygen consumption and replenishment in the body and makes open or more susceptible to diseases such as emphysema and bronchitis

Table 3 summarizes the quality ratings assigned to studies by health outcome, with inter-rater agreement on 49 out of 53 (92%) for quality and level of evidence categoriese