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Furthermore, UA significantly enhances the expression of Kv1.5 protein and enhances Akt and HSF1 phosphorylation, leading to increased Hsp70 expression

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Since the levels of iron derived from mainstream cigarette smoke is too low to cause iron accumulation in the lungs 8 , CSE-initiated iron accumulation and cell death may arise from defects in intracellular iron metabolism via ferritinophagy rather than by an increase in iron uptake