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An estimated 5.6 million children up to 17 are projected to die too early from tobacco-related illnesses

-Smoking was a way for women in the 1920s to signal their independence and avant-garde social outlook

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The main features of initial epithelial injury are mucociliary dysfunction, goblet cell hyperplasia, and disruption of tight junction proteins, changes that together impair mucociliary clearance and compromise barrier integrity ( Expansion Phase Immune cell recruitment mediator release critical pathway activation transition to senescence Small airway inflammation is induced by chronic exposure to cigarette smoke and atmospheric particulate matter

Adolescent brains are still developing and vaping may have negative effects on addiction, cognition and emotional regulation