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Perceptions of appeal were more strongly associated with perceptions of attractiveness than harm, which was observed overall and within each brand feature

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In addition, perfusion abnormalities were worse in patients using nicotine-based e-liquids as compared to those using nicotine-free e-liquids, which points towards known impacts of nicotine on cardiovascular hemodynamics, increases in heart rate, systolic blood pressure and cardiac output (107)

Methods Human subjects and blood collection Thirty heavy smokers (defined as current smokers smoking 1 pack/day for at least 20 years) and 36, healthy never smokers volunteers were recruited

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