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Since the scoping review aims to analyze the content and scope of the frameworks regarding the target groups and upstream actions, the data extraction consists of three steps and has two purposes: 1) to identify which frameworks are used in the literature and for which evaluation data may be available

FDA received nearly one million applications for synthetic nicotine products and as of October 14, 2022, issued over 60 warning letters to synthetic nicotine product manufacturers that did not even bother to submit applications to stay on the market