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Pharmacokinetics (PK) - plasma nicotine Blood samples for the measurement of plasma nicotine concentrations were taken by direct venipuncture at 10 min prior to, and at 5, 10, 15, 20, 25, 30, 45, 60, 75, and 90 min following the start of the controlled product usage on Days 1, 3, 5, 7, 9, and 11

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