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Behavioral changes have also been observed even in the absence of nicotine, as nicotine-free electronic cigarette vapor exposure was shown to result in anxiogenic phenotypes in both male and female mice (81)

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Instead, it should boast high-quality tobacco content to help provide cigar smokers with a satisfying hit in every puff

Nicotine has been linked to harmful effects on the fetus in animal studies, although there is currently no evidence that these findings apply to humans

Thus, the Swiss underreporting of daily cigarettes is plausibly between 7.3% (like France) and the upper limit of 32% (like the USA)