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Food and Drug Administration (FDA) as Generally Recognized As Safe (GRAS) for use as a direct food additive, including frozen foods such as ice cream and frozen desserts.The GRAS designation is specific to its use in food, and does not apply to other uses

doi: 10.1080/1047322X.1990.10389587 44 CDC

This points to yet another confirmatory data point in support of Jha et al and Thun et als finding that smokers life spans are cut short by over a decade

Electronic cigarette use prevalence, associated factors, and pattern by cigarette smoking status in the United States from nhanes (National health and nutrition examination survey) 2013-2014