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Of note, in our population most of this effect was driven by an increase in the late diastolic component of mitral annulus motion (Figure 5, top panels), with only a nonsignificant trend towards a reduction in the early diastolic component

Although this work did not directly address the role of specific receptors within the cholinergic and/or noradrenergic systems, it increased the awareness of how different receptor agonists and antagonists may contribute to depressive or antidepressant effects

However, it may interact with various drugs, potentially altering their effectiveness or increasing the risk of side effects

Sci Rep 8 , 13643 (2018)

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