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Our findings reveal a decreased PPAR expression in dual-culture conditions (without macrophages) and a significant upregulation in triple-culture conditions (with macrophages) upon cigarette smoke exposure (Supplementary Fig

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Over subsequent years, this was progressively reduced to 0.7 grams in 2020 and will further reduce to 0.6 grams by 2026see Section 13.6.3.7 Harmonisation of roll-your-own tobacco excise for further information