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Table 3 summarise the role of non-CYP450 proteins involved in drug metabolism/transport and impact of cigarette smoking

Musculoskeletal System Quitting smoking improves blood flow to the muscles and bones , leading to reduced stiffness and enhanced mobility

Propensity score matching attenuated the inverse associations and rendered them non-significant, suggesting healthy switcher bias and residual confounding rather than a protective effect of e-cigarette use

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