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These include: Major trauma Cancer Being 55 and older Having a personal or family history of blood clots Immobility (such as being on bed rest or difficulty with walking) Pregnancy, or using estrogen containing medications such as birth control pills, patches, and hormone replacement therapy Obesity Smoking Almost half of all blood clots occur either during or soon after discharge from a hospital stay or following surgery

In fact, a 2015 study suggested a very rare genetic mutation may protect some smokers from never getting sick, although not give completely immunity, The Independent reported