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High reinforcing efficacy of nicotine in non-human primates
It claims it merely supports healthy competition and motivates existing smokers to switch brands
There are "very important considerations, starting with legal considerations, about getting this right as we move forward in the rulemaking," FDA Center for Tobacco Products director Mitch Zeller said at a briefing
Data analysis Unsupervised principal component analysis (PCA) was first used to observe the overall distribution of samples and the stability of the analysis, followed by supervised partial least-squares discriminant analysis (PLS-DA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) used to distinguish the differences in metabolic profiles
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