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These can be distinguished from the intravascular CD14+ monocytes by their expression of CD206 as well as other markers CD141, CD11c, human leukocyte antigen DR (HLA-DR) and CC-chemokine receptor type 7 (CCR7), with CD1a and CD1c allowing further categorisation of these cells.14 Phenotype and normal function in airways Macrophages have been shown to exhibit plasticity and can change their phenotype depending on the local environment