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Tobacco use is a global health crisis

It would need a 9 or 11-letter counterpart in the themers to balance it out, and no such answer exists (and if it did exist, would certainly make the grid way too crowded with theme material), so we get this semi-ugly but still effective compromisea broken two-part themer

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Replacement Nicotine's Real-World Failure While NRT generally clobbers users of placebo NRT look-a-likes inside randomized clinical trials, placebo isn't a real quitting method