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Detailed analyses of patterns of use of ECs and HTPs exclusively and in combination with CCs are needed to assess in detail how users approach these products and, in particular, to understand how short-term effects such as adverse events vary with different patterns of product use (e.g

Smokeless-tobacco-consuming healthy samples were observed to have a higher intra-sample diversity (Shannon and Simpson index) than smokeless-tobacco-non-consuming samples ( Supplementary Figure S1B )

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