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This is unsurprising given that after combining results within each subject we had very small sample sizes (e.g., n = 3 sheep for MMP-9 activity) and highlights the need for further verification

These reservoirs come in different shapes and sizes, and some can be refilled

In light of its superior safety profile, Health Canada mandated a label change in 2013 advising thorough consideration of NRT before prescribing either varenicline or bupropion to any smoker, further stating that in many cases, nicotine replacement therapy should be tried before prescribing varenicline or bupropion [9], emphasizing the need to optimize the effectiveness of this first-line medication