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To reduce flexibility to favour crystallization, a disulfide bond was introduced in a flexible loop connecting the -sheet segment to the two -helices of CYTX, yielding a candidate (CYTX_B10) with improved thermal stability ( T m = 70.3 C) and monomeric profile during SEC, but a slightly weaker K d of 740 nM for N
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**Other Players: Godfrey Phillips and VST Industries are also facing similar pressures, with #analysts expecting a 15% or higher drop in #sales volumes in the near term due to #tax hikes A new excise duty (2,050 to 8,500 per 1,000 cigarettes) was introduced, effective February 1, 2026