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[23] These findings lead to the conclusion that the large quantities of free radicals contained in smoke enhance oxidative stress and, in combination with reduced NO bioavailability, nicotine-induced vasoconstriction and impaired vasodilation, may lead to endothelial dysfunction

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The next step will be a UK-style ban, raising the age of sale every year until no-one can legally purchase cigarettes and other tobacco products. The reported on Tuesday how Health Minister Stephen Donnelly, who has previously stated his intention to raise the age of sale from 18 to 21, plans to bring a memo to Cabinet within weeks seeking government approval to proceed with legislation