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In addition to headaches, nicotine withdrawal can include other physical or psychological symptoms such as: strong cravings for nicotine irritability restlessness or having trouble concentrating anxiety depression difficulty sleeping vivid dreams dizziness sweating constipation nausea Nicotine withdrawal symptoms can be unpleasant
Among its unique features, mtDNA is considered a damage-associated molecule because its mislocalization from the mitochondria to the cytosol or extracellular space (including the blood circulation) can trigger the innate immune system by engaging multiple DNA-sensing receptors (DSRs) and activate downstream proinflammatory signaling cascades
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