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In general, chronic exposure to nicotine may cause an acceleration of coronary artery disease, peptic ulcer disease, reproductive disturbances, esophageal reflux, hypertension, fetal illnesses and death, and delayed wound healing

To combat the trend in e-liquid related nicotine poisonings, the federal government passed a bill in 2016 to introduce on all e-liquid packaging

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In 2020 the FDA proposed new graphic warning labels and articulated a more specific government interest statement (Federal Register 2019, 2020)

This measure also applies the tobacco products excise tax to electronic cigarettes that contain nicotine or are sold with liquid containing nicotine (hereafter referred to as e-cigarettes)