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Interestingly, this study found that nicotine itself was not responsible for this delay, suggesting other compounds in cigarette smoke might be the causative agents

The arrest led to a case that made its way to the state's Supreme Court after a lower court held that the transporter requirement placed an "undue burden on interstate commerce."[44] In 1953 the Michigan Supreme Court ruled that the license requirement did not in fact interfere with interstate commerce

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