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Finally, Table 4 and Figure 3 show the results of applying the clustering algorithm to test for the existence of subgroup convergence for the second analyzed subperiod (20112021)

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OSCC-associated microbiomes showed enrichment of Gram-negative genera such as Prevotella , Capnocytophaga , and Fusobacterium , linked to the lipopolysaccharide biosynthesis pathway, highlighting their potential as markers for oral cancer [77]