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In fact, much more research is required to establish whether pure nicotine has detrimental or good effects, although it can be stated that many of the consequences induced by cigarette smoke, particularly in respiratory problems, are caused by other components in cigarette smoke

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Hydrogen cyanide : Considered one of the most toxic agents in tobacco smoke, hydrogen cyanide is associated with numerous short-term and long-term toxic effects like weakness, restlessness, nausea, and vomiting