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a simple complaint about an e-cigarette retailer can prompt regulatory agencies to launch an investigation, creating additional exposure and negative publicity for vape and e-cigarette companies and marketers

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On September 28th, 2021, Thingiverse user SimBim uploaded a 3D printable design for a "Double Cigarette Adapter" to the site

Glossary AAV-T4 adeno-associated virus-T4 AECI alveolar type I epithelial cells AECII alveolar type II epithelial cells AECs alveolar epithelial cells ALI acute lung injury AMs alveolar macrophages AMP adenosine 5-monophosphate AMPK AMP-activated protein kinase ARDS acute respiratory distress syndrome ARE antioxidant response element ATP adenosine triphosphate BACs bronchoalveolar cells BALF bronchoalveolar lavage fluid BLM bleomycin BNIP3 BCL2 interacting protein 3 Ca 2+ calcium ions CL lipid cardiolipin cPLA2 cytoplasmic phospholipase A2 CSE cigarette smoke extract Cx43 connexin 43 DAMPs damage-associated molecular patterns Drp1 dynamin-related protein 1 EMT epithelial-mesenchymal transition eNAMPT extracellular nicotinamide phosphoribosyltransferase Fis1 fission 1 FUNDC1 FUN14 domain containing 1 gadd7 growth-arrested DNA damage-inducible gene 7 GM-CSF granulocyte-macrophage colony-stimulating factor GSH-Px glutathione peroxidase GTPases guanosine triphosphate hydrolases HDACs histone deacetylases HDAC3 histone deacetylase 3 HO-1 heme oxygenase-1 HSPB8 heat shock protein B8 IL interleukin IMM inner mitochondrial membranes IPF idiopathic pulmonary fibrosis KD knockdown KEAP1 Kelch-like ECH-associated protein 1 LC3 light chain 3 lncRNA long non-coding RNA L-OPA1 long OPA1 LSD1 lysine-specific demethylase 1 MAPK mitogen-activated protein kinase Mdivi-1 mitochondrial division inhibitor-1 MERCs mitochondria-endoplasmic reticulum contact sites Mff mitochondrial fission factor Mfn1 mitofusin 1 MiD49 mitochondrial dynamics proteins of 49 kDa MiD51 mitochondrial dynamics proteins of 51 kDa MLE murine lung epithelial MSCs mesenchymal stem cells mtDNA mitochondrial DNA mtROS mitochondrial reactive oxygen species MyD88 myeloid differentiation primary response protein 88 NDP52 nuclear dot protein 52 NEAT1 nuclear enriched abundant transcript 1 NF-B nuclear factor kappa-B NIX NIP3-like protein X NLRP3 NOD-like receptor protein 3 NR4A1 nuclear receptor subfamily 4 group a member 1 Nrf2 nuclear factor erythroid 2-related factor 2 OE overexpression OMM outer mitochondrial membranes OPA1 optic atrophy 1 OPTN optic nerve phosphodiesterase OXPHOS oxidative phosphorylation PD-L programmed death-ligand PF pulmonary fibrosis PGE2 prostaglandin E2 PINK1 PTEN-induced putative kinase 1 PQ paraquat Prdx3 Peroxiredoxin 3 PGC-1 PPARcoactivator 1 PPAR- peroxisome proliferator-activated receptor- PRDX2 peroxiredoxin-2 PTPN21 non-receptor protein tyrosine phosphatase 21 RHOA ras homolog gene family ROS reactive oxygen species, member A Sirt Sirtuins SOD superoxide dismutase S-OPA1 short OPA1 Stat2 signal transducers and activators of transcription 2 T4 Thymosin 4 TBC1D15 TBC domain family member 15 TFEB transcription factor EB TFF2 trefoil factor 2 TGF transforming growth factor TLRs Toll-like receptors TOM translocase of the outer mitochondrial membrane ULK1 UNC-51-like kinase 1 YAP yes-associated protein References 1 AdebayoM.SinghS.SinghA