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Authors Note: Olabode Ekerin is also affiliated to College of Education and Human Sciences, University of Nebraska-Lincoln, Nebraska, USA

This is a hallmark of addiction, where users need progressively larger amounts of the substance to experience the desired effects

Triantafyllou GA, Tiberio PJ, Zou RH, Lamberty PE, Lynch MJ, Kreit JW, et al

Varenicline works by binding to nicotine receptors in the body, partly turning them on to reduce withdrawal symptoms, but also blocking them from the nicotine in cigarettes and thus making smoking less pleasurable

She was constantly reminding me, 'Helen, smoking causes cancer!' This time I wasn't able to stop smoking even while wearing the patch