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6 Hematopoietic System Chronic tissue hypoxia leads to a compensatory increase in red blood cell production and nonspecific myeloproliferation (white blood cells, platelets, and clotting factors), increasing plasma viscosity and a prothrombotic state

CONCLUSIONS Smoking of cigarettes is a concern as it is an essential cause of inhalation of highly toxic elements, not only to the smoker but also, through passive smoking, to non-smokers

[56] Tobacco-specific impurities such as cotinine, nicotine-N'-oxides ( cis and trans isomers), and beta-nornicotyrine are believed to be the result of bacterial action or oxidation during the extracting of nicotine from tobacco