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However, an independent study of the cytotoxicity of IQOS smoke on human vascular endothelial cells compared to cigarettes and other HTPs showed induced mitochondrial activity

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[53] The effectiveness of vaping for quitting smoking among vulnerable groups is uncertain

[19] [45] In November 2018 the FDA announced its intention to outlaw menthol cigarettes, later changing this position to advocate for restriction of flavored tobacco and e-cigarettes to a separate age-restricted room