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HPHCs have been defined by the US Food and Drug Administration (U.S FDA) as chemicals or chemical compounds in tobacco products or tobacco smoke that cause or might cause harm to smokers or non-smokers 38,39

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Price differences within the EUs internal market also create incentives for smuggling and re-imports from neighbouring countries, putting legal suppliers under enormous pressure. The trade in e-cigarettes from irregular sources also raises safety and consumer protection concerns , as these products can (and do) circumvent the quality controls, labelling requirements, and authorisation procedures laid down by European legislation