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Although the FDA has approved bupropion to be used for 150 mg per day for three days, then increased to 300 mg per day on the fourth day (Physicians Desk Reference, 2011), the authors have found it to be too rapid of an increase that tends to precipitate unnecessary side effects (e.g., insomnia, tremor, irritability, agitation)

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Attempts by some nations to do this have often been met with failures.

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For further information, contact Professor Geoffrey T