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Impairment of Endothelial Function by Cigarette Smoke is not Caused by a Specific Smoke Constituent, but by Vagal Input from the Airway In the rat study, arterial flow-mediated dilation (FMD), which is the ability of the blood vessels to widen, was measured pre- and post-exposure to smoke from four kinds of traditional combustible cigarettes: conventional nicotine, reduced nicotine, conventional nicotine with added menthol and reduced nicotine with added menthol