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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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Future research to identify other susceptibility factors, such as genes that modify carcinogen metabolism or DNA repair, will need to be substantially larger and to quantify lifetime tobacco exposure with more precision than have past studies in order to distinguish gradations in risk due to exposure from those caused by genetic susceptibility

Did you know that when Tim Wakefield threw the first ten innings of a game on April 27, 1993, it was the most innings pitched in a game by a Pirates pitcher since John Smiley on July 6, 1989