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IL-1 and IL-1 receptor signaling initiated by AMs (11) activates bystander cells to produce the key proinflammatory cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) (65), TNF (11, 12), or interleukin-12 (IL-12) (11, 13), all of which are required for an efficient anti- Legionella immune response

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Using multiple regression methods, the investigators evaluated the associations between daily mean temperature, relative humidity, and UV radiation and the spread of the virus from early January to early March in the 224 cities