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Moreover, in human small airway epithelial cell lines (HSAEpiCs), uPA and uPAR inhibition can block CSE-induced EMT by reversing the expression of E-cadherin and -catenin and delaying the induction of N-cadherin and Vimentin [174, 175]

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Additional support came from the University of California Tobacco Related Disease Research Program and the National Cancer Institute and Food and Drug Administration Center for Tobacco Products