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The GAO didn't directly address whether the substitution had undermined the attempt to prevent price sensitive teens from starting to smoke

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In one study, just 4.2% of smokers had a clozapine plasma level greater than 1000 g/L, the threshold beyond which the risk of convulsive seizures increases

If that drags on much longer, its a problematic situation because of course theres confusion at retail and, more significantly, the companies that are following the rules are really suffering as a result, Howard said