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By 1560, tobacco was known throughout Europe as a medicinal plant thanks to Jean Nicot, the French ambassador to Portugal

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Smoking poisons this lining and cripples its nitric-oxide production the loss of nitric-oxide availability is the single best-established mechanism linking cigarettes to ED (Tostes, 2008)

This alignment directly supports several Sustainable Development Goals outlined in the 2030 Agenda [124], as cigarette butts contamination and pollutants leakage threatens Good health and well-being (Goal 3), Clean water and sanitation (Goal 6), and Life below water and on land (Goals 14 and 15) by exposing populations and biota to pollution from microplastics and toxic substance leakage

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