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Further reading Ashes to Ashes: The History of Smoking and Health (1998) edited by S

In a review of studies looking at smoking cessation interventions for adults, nicotine patches improved continued abstinence from smoking at 6 months, and nicotine gum improved continued abstinence from smoking at 12 months

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Some of these effects were found to be through nicotine activation of NF-B signalling albeit in females but not in males