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"Making cigarettes and other combusted tobacco products minimally addictive or nonaddictive would help save lives." The FDA funded a randomized trial published in 2018 that found "reduced-nicotine cigarettes versus standard-nicotine cigarettes reduced nicotine exposure and dependence and the number of cigarettes smoked." Another FDA-funded study found that, if a nicotine reduction policy were enacted in 2020, it could result in more than 33 million people not becoming regular smokers, and prevent more than 8 million deaths from tobacco-related illnesses by 2100

In the mid-20th century, Camel ran the famous More Doctors Smoke Camels Than Any Other Cigarette campaign

During this time, overall prevalence decreased by more than half, despite some fluctuation

Medicines and Healthcare Products Regulatory Authority