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Plasma samples were spiked with 0.05% aqueous formic acid containing a deuterated internal standard of cotinine, extracted with a solid phase resin, and analyzed using LC-MS/MS via multiple reaction monitoring (MRM) to quantitate cotinine

Common substances include: Propylene Glycol and Glycerin : These are the base components of most e-liquids, and when heated, they can break down into toxic chemicals like formaldehyde and acetaldehyde

Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors

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Plaque buildup can increase the risk of heart disease, which can cause heart attack