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The epoxide diol from benzo[a]pyrene is particularly dangerous because the large flat portion of them molecule likes to slide inbetween the bases of double stranded DNA (a process called intercalation), facilitating attack by nucleophilic sites on DNA at the electrophilic epoxide

Key contributing factors include limited access to the HBV vaccine in certain countries, noncompliance with multi-dose regimens, and the presence of vaccine non-responders, estimated at 16% of the population, which are more prevalent among older individuals, those with obesity, and smokers 8,9,10,11

Long-term health impacts remain under investigation

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"How is 21 going to limit that availability