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Much like quetiapine (Seroquel), which actually resembles clozapine and is related to it on a molecular level, clozapine is a heavy sedative and much better tolerated when given all at night

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10.1136/tobaccocontrol-2020-055733 Tobacco Control 24 WangM.LuoX.XuS.LiuW.DingF.ZhangX.et al (2019)